TEZSPIRE is an add-on maintenance treatment for people aged 12 and older with severe asthma or inadequately controlled chronic rhinosinusitis with nasal polyps (CRSwNP). It’s not for sudden breathing problems.

Welcome to Start Smart, where you'll find resources to help support your TEZSPIRE journey.

Watch intro

Your TEZSPIRE journey begins here

Read the Instructions for Use before you start using your TEZSPIRE Pre-filled Pen. If you have further questions, please contact your doctor.

Watch this video for more information on these important first steps. 

Watch this video for more information on these important first steps.

Your doctor sends your prescription to a specialty pharmacy.

Setting up delivery with your specialty pharmacy

Your specialty pharmacy will contact you to coordinate shipment, so be sure to save their number on your phone. You can also request a free sharps disposal container when they call.

What to do when your treatment arrives

Leave your TEZSPIRE pen in its original carton and place it directly in the refrigerator.*

*Store TEZSPIRE in a refrigerator between 36 °F and 46 °F (2 °C and 8 °C) in its original carton until you’re ready to use it. Store TEZSPIRE in the original carton to protect it from light.

To learn more about storing the TEZSPIRE Pre-filled Pen, see our Self-Injection Journey Guide.

Preparing to use TEZSPIRE

Remove your TEZSPIRE Pre-filled Pen from the refrigerator about 60 minutes before use to allow it to reach room temperature,† and use within 30 days of removal from the refrigerator. Make sure the liquid is colorless to light yellow.

†Do not put the TEZSPIRE Pre-filled Pen back in the refrigerator after it has reached room temperature. Dispose of the pen if it has been stored at room temperature between 68 °F and 77 °F (20 °C and 25 °C) for more than 30 days.

How to take TEZSPIRE

This resource is intended to provide you with an overview and basic information about injecting your medication and does not replace the Instructions for Use. Prior to administering your medication, thoroughly review the complete Instructions for Use. If you have any questions, please contact your doctor.

How to use your TEZSPIRE Pre-filled Pen

The demonstration in the video gives you basic information about the TEZSPIRE Pre-filled Pen. It is important that you also thoroughly review the Instructions for Use. These instructions cover everything you need to know about how to use TEZSPIRE. The information on this website does not replace the Instructions for Use.

Keep track of your injections and set up alerts with your calendar app

Schedule reminder

Want the injection log on your device?

Download PDF

The TEZSPIRE Together Co-pay Program

Enroll today and you may pay as little as $0* for each dose of TEZSPIRE.

Start enrollment

If you’re already enrolled, look up your co-pay card information to share with your provider or specialty pharmacy.

Co-pay card lookup

*For commercially insured patients only. Eligibility and program maximums apply. No income requirements. Please click to see full Terms and Conditions.

How TEZSPIRE has helped others—and how it can help you

I know my asthma will always be there, but it's just not so much on the forefront anymore. And for that, I am very grateful.

– Julie, TEZSPIRE patient

Individual results may vary.

Hear real stories from people taking TEZSPIRE, and share your own to help guide others on their treatment journey.

TEZstimonials

What are the benefits of TEZSPIRE?

TEZSPIRE is proven to help prevent asthma attacks, improve lung function, and relieve symptoms.

For those with nasal polyps, it's proven to help shrink polyps and reduce nasal congestion.

Important Safety Information

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Important Safety Information

Do not use TEZSPIRE if you are allergic to tezepelumab-ekko or any of its ingredients.

Do not use to treat sudden breathing problems.

TEZSPIRE may cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after your TEZSPIRE injection. Allergic reactions can sometimes happen hours or days after you get a dose of TEZSPIRE. Call your healthcare provider or get emergency help right away if you get any of the following symptoms of an allergic reaction:
    • rash
    • breathing problems
    • hives
    • red, itchy, swollen, or inflamed eyes
    • swelling of your face, mouth, and tongue
    • fainting, dizziness, feeling lightheaded

Before using TEZSPIRE, tell your healthcare provider about all of your medical conditions, including if you:

  • have ever had a severe allergic reaction.
  • have a parasitic (helminth) infection.
  • have recently received or are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with TEZSPIRE.
  • are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breastfeed. It is not known if TEZSPIRE passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use TEZSPIRE.
  • are taking prescription and over-the-counter medicines, vitamins, or herbal supplements.

Do not change or stop taking your other asthma medicines unless instructed to do so by your healthcare provider.

The most common side effects of TEZSPIRE include: Sore throat, joint and back pain, common cold symptoms, flu, upper respiratory tract infections, injection site reactions, and nose bleeds. These are not all the possible side effects.

Approved Use

TEZSPIRE is a prescription medicine used:

  • with other asthma medicines for the maintenance treatment of severe asthma in people 12 years of age and older whose asthma is not controlled with their current asthma medicine.
  • with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) in people 12 years of age and older whose CRSwNP is not controlled with their current CRSwNP medicine.

TEZSPIRE helps:

  • prevent severe asthma attacks (exacerbations) and can improve your breathing.
  • reduce the size of your polyps, improve symptoms including i.e. nasal congestion and loss of smell, and reduce the need for oral corticosteroids and surgery for your nasal polyps in CRSwNP.

TEZSPIRE is not used to treat sudden breathing problems. Tell your healthcare provider if your asthma does not get better or if it gets worse after you start treatment with TEZSPIRE.